Tuesday, April 30, 2013

House, Senate move to fix typo in FAA measure

WASHINGTON (AP) ? The tale of the missing "s'' is about to end.

The Senate and House moved on Tuesday to restore the missing letter to the word "accounts" in a bill that will allow the Federal Aviation Administration to withdraw its furloughs of air traffic controllers.

Lawmakers had rushed to pass the bill last week before lawmakers left town for their weeklong break. The typo had held up the bill and President Barack Obama was unable to sign it.

The furloughs had caused coast-to-coast flight delays that angered thousands of travelers. The FAA was already resuming normal operations, moving ahead despite the technical glitch in the legislation.

Source: http://news.yahoo.com/house-senate-move-fix-typo-faa-measure-150425660.html

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Secondhand smoke presents greater threat to teen girls than boys

Apr. 30, 2013 ? When teenage girls are exposed to secondhand smoke at home, they tend to have lower levels of the "good" form of cholesterol that reduces heart disease risk, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

High-density lipoproteins (HDL) pick up excess cholesterol in the blood stream and take it to the liver where it can be broken down. Unlike low-density lipoproteins that can create a waxy build-up that blocks blood vessels, HDL cholesterol can play a key role in combatting heart disease risk.

"In our study, we found 17-year-old girls raised in households where passive smoking occurred were more likely to experience declines in HDL cholesterol levels," said the study's lead author, Chi Le-Ha, MD, of the University of Western Australia. "Secondhand smoke did not have the same impact on teenage boys of the same age, which suggests passive smoking exposure may be more harmful to girls. Considering cardiovascular disease is the leading cause of death in women in the western world, this is a serious concern."

Researchers studied a longitudinal birth cohort of 1,057 adolescents who were born between 1989 and 1992 in Perth, Australia. The study gathered information about smoking in the household beginning at 18 weeks gestation and leading up to when the children turned 17. During that time, 48 percent of the participants were exposed to secondhand smoke at home. Blood tests were performed to measure the teenagers' cholesterol levels.

"The findings indicate childhood passive smoke exposure may be a more significant cardiovascular risk factor for women than men," Le-Ha said. "We need to redouble public health efforts to reduce young children's secondhand smoke exposure in the home, particularly girls' exposure."

Other researchers working on the study include: L. Beilin, S. Burrows, R. Huang, W. Oddy and T. Mori of the University of Western Australia and B. Hands of Notre Dame University in Perth, Australia.

The article, "Gender Difference in the Relationship between Passive Smoking Exposure and HDL-Cholesterol Levels in Late Adolescence," appears in the May 2013 issue of JCEM.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/heart_disease/~3/qPfOfT2E6fk/130430131449.htm

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Template for peace

Template for peace [ Back to EurekAlert! ] Public release date: 29-Apr-2013
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Contact: Megan Beech
m.beech@hud.ac.uk
01-484-473-053
University of Huddersfield

Focused between 1972 and 1975, the most violent and polarised years of the Northern Ireland conflict, this book challenges a number of persistent myths, including those concerning the role of the Irish government in the Northern Ireland conflict. It contests the notion that the years 1972 to 1975 represent a 'lost peace process', but demonstrates that the policies established during this period provided the template for Northern Ireland's current, ongoing peace settlement. Using archival sources, this book analyses the political events and processes that informed the British government's Northern Ireland policy at the time, the complex interactions between Northern Ireland political parties, and the importance of the British-Irish diplomatic relationship to the search for a solution to the Northern Ireland conflict.

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Source: http://www.eurekalert.org/pub_releases/2013-04/uoh-tfp042913.php

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Following Entrepreneur Visa Approval, TechStars London Finds A Permanent Home In The UK

warner-yard-1TechStars London, the UK outpost of uber-accelerator TechStars has announced that its found a permanent home at newly-established Warner Yard, a co-working space owned by early-stage fund Playfair Capital. It follows the recent news that TechStars London has been approved as a Recognised Seed Competition, smoothing the way for participants to qualify for a UK Entrepreneur Visa.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/N4NrACN-3Oc/

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Monday, April 29, 2013

Edward Jay Epstein: The Amanda Knox Circus -- Again

Amanda Knox, even while appearing on prime time television in America to promote her book Waiting to Be Heard, is facing yet another murder trial in Italy for a crime -- of which, in 2011, after spending four years in prison, she was found innocent by an Italian appeals court. In throwing out the murder case against her, that court declared that the prosecution's charges were "not corroborated by any objective element of evidence." The revival of the baseless charges against Knox, and the tabloid frenzy it will no doubt stoke, proceeds from a five-year-long judicial circus in Italy.

Amanda Knox's ordeal began on November 1, 2007 with the brutal murder of Meredith Kercher, a 21-year-old British exchange student, in a ground-floor flat in a cottage shared by four young women in Perugia, Italy. When police arrived the next morning, they found Kercher's body with several knife wounds, her clothing strewn around, and a broken window. They did not find a murder weapon. It was a holiday weekend; the seven other tenants of the cottage -- including four men in the basement flat -- all claimed to have been away on the night of the murder, including one other exchange student who was there when the police arrived: Amanda Knox. Knox, an angel-faced 20-year-old student from Seattle, Washington, told police that she had spent the night at the home of her new boyfriend Raphaele Sollecito. Sollecito, who was standing with her, confirmed her alibi.

While the police investigators had no immediate witnesses to the murder and no murder weapon, they had a blood-stained bedroom in which the coroner determined that the victim was sexually assaulted and stabbed to death. This crime scene was crucial to solving the case since as the great French criminologist Edmond Locard suggested nearly a century ago, even the most careful criminal is likely to leave behind a hair, clothing fiber, a fingerprint or other trace of himself or herself. The crime scene in Perugia contained more than enough such clues fully to identify the assailant. There were 14 identifiable fingerprints in the room, a palm print on the blood-stained pillow under the victim's body, a sneaker print in the blood on the floor. DNA of a person other than Sollecito or any other tenant was found inside Kercher's vagina and on her purse. (Kercher's money was missing from that purse.) All those clues were marks of a single individual, though it took over a month to identify him. He was Rudy Guede, a 20-year-old drifter from the Ivory Coast, who had broken into other homes in the area. Less than a week before the murder, Guede had even been temporarily detained by police in Milan for breaking into a nursery and stealing an 11-inch kitchen knife.

The crime scene could establish from Guede's fingerprints that he had been inside the victim's room, from his DNA inside Kercher's vagina that he had had sexual contact with her, and from his sneaker impression found on the floor in her blood, his palm print found in her blood on the pillow, and his DNA found on her purse, that he had been in the room after she was stabbed. His description, moreover, fit that of a black man whom two witnesses had seen on the street running away from the cottage that night

Shortly after the murder, Guede had fled to Germany. It took more than a month to capture him. He was then extradited to Italy, tried, and in October of 2008, convicted of both the sexual assault upon Kercher and Kercher's murder.

The belated identification of a local burglar as the intruder and sexual assailant did not, however, end the ordeal of Amanda Knox. In the interim, the chief prosecutor, Giuliano Mignini had developed a theory that Knox - whom he described as a "she-devil" -- had murdered her roommate and staged the evidence of a break-in. Knox had been imprisoned. For Mignini to abandon his "she-devil" theory, even after Guede's arrest, could prove an embarrassment. In an earlier, so-called "Monster of Florence case," he had already advanced a "Satanic theory" -- in which he attributed a string of unsolved murders to a Satanic cult who killed young women to use their body parts in black masses. His efforts in that pursuit of a non-existent cult resulted in him being criminally indicted for prosecutorial misconduct. (He was still under that indictment in 2007.) If his "she-devil" characterization of Knox were to fail as well, the prosecutor might be further discredited.

The solution Mignini now found was to expand the "she-devil" theory to include Guede, and to claim that Knox teamed up with Guede and her boyfriend to kill her flat mate after a sex game.

The initial crime scene investigation had not produced a shred of evidence that Knox had been in the room at the time of the murder. Under interrogation, Knox had, however, lied to police. She had falsely told them that she had witnessed the Congolese-born owner of a nearby bar, Patrick Lumumba, murder Kercher. Knox had worked part-time for that bar. Lumumba denied having ever been at the cottage. He was, nonetheless, arrested -- as were Knox and her boyfriend Sollecito. Lumumba was fortunate enough to have a solid alibi for the night of the murder. He was released. Knox repudiated her accusation. In her new book, Waiting to Be Heard, she says the accusation was a pure fabrication, induced by police intimidation.

The false statement makes Knox a liar, but not at all, by implication, a murderer. A recent study of criminal justice in the U.S. by law professor Brandon Garrett shows it is not uncommon for innocent people to lie under police pressure; indeed no fewer than 40 people out of 250 who were convicted and later exonerated by DNA evidence, had falsely confessed to crimes they did not commit.

In Knox's case, Italian prosecutors in their subsequent investigation did find two bits of DNA that could support a conspiracy theory. The first was taken from a knife found in Sollecito's kitchen and matched Knox's DNA. The second bit of DNA was taken from Kercher's bra clasp and matched Sollecitto's DNA. As it turned out, both DNA samples were later invalidated by the appeals court because of a serious flaw: the police technician who examined them had failed to change her lab gloves between examining DNA samples, raising the possibility of cross-contamination. That "evidence" was invalidated, leaving none. In the absence of any physical evidence against them, Knox and Sollecito were acquitted by the appellate court.

In Italy, prosecutors have the right to appeal an acquittal. On March 25, 2013, at the request to the prosecutor, a court of Cassation overturned the acquittal of Knox, ordering her to be tried again for a crime, which an appellate court had found there was absolutely no evidence that she committed. The United States Constitution, under its double jeopardy provisions, protects individuals from being retried for crimes of which they have been acquitted. It would be a violation of Knox's constitutional rights as a United States citizen to return her to Italy to be tried again. It would also, of course, be a travesty of justice for an Italian prosecutor to use her case as a means to revive a his reputation, as an advocate of Satanic and "she-devil" conspiracy theory.

Edward Jay Epstein is the author of Annals of Unsolved Crimes

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Source: http://www.huffingtonpost.com/ed-epstein/amanda-knox-italy_b_3174771.html

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/302172562?client_source=feed&format=rss

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How Earthquakes in Chile Have Permanently Deformed Earth

Earthquakes can permanently crack the Earth, an investigation of quakes that have rocked Chile over the past million years suggests.

Although earthquakes can wreak havoc on the planet's surface, more than a century of research has suggested the Earth actually mostly rebounds after quakes, with blocks of the world's crust elastically springing back, over the course of months to decades, to the way they initially were. Such rebounding was first seen after investigations of the devastating 1906 San Francisco temblor thathelped lead to the destruction of more than 80 percent of the city. The rebound is well-documented nowadays by satellite-based GPS systems that monitor Earth's movements.

However, structural geologist Richard Allmendinger of Cornell University and his colleagues now find major earthquakes of magnitude 7 or greater apparently caused the crust in northern Chile to crack permanently. [The 10 Biggest Earthquakes in History]

"My graduate students and I originally went to northern Chile to study other features," Allmendinger said. "While we were there, our Chilean colleague, Professor Gabriel Gonz?lez of the Universidad Cat?lica del Norte, took us to a region where these cracks were particularly well-exposed."

"I still remember feeling blown away ? never seen anything like them in my 40 years as a geologist ? and also perplexed," Allmendinger told OurAmazingPlanet. "What were these features and how did they form? Scientists hate leaving things like this unexplained, so it kept bouncing around in my mind."

Atacama exposed

In northern Chile, "the driest place on Earth, we have a virtually unique record of great earthquakes going back a million years," Allmendinger said. Whereas most analyses of ancient earthquakes only probe cycles of two to four quakes, "our record of upper plate cracking spans thousands of earthquake cycles," he noted.

The record of the vast number of earthquakes captured in northern Chilean rocks allowed the researchers to examine their average behavior over a much longer period of time, which makes it easier to pick out any patterns. They discovered that a small but significant 1 to 10 percent of the deformation of the Earth caused by 2,000 to 9,000 major quakes over the past 800,000 to 1 million years was permanent, involving cracks millimeters to meters large in the crust of the Atacama Desert. The crust may behave less elastically than previously thought.

"It is only in a place like the Atacama Desert that these cracks can be observed ? in all other places, surface processes erase them within days or weeks of their formation, but in the Atacama, they are preserved for millions of years," Allmendinger said. "We have every reason to believe that our results would be applicable to other areas, but is simply not preserved for study the way that it is in the Atacama Desert," he added.

Model rethink

This work "calls into question the details of models that geophysicists who study the earthquake cycle use," Allmendinger said. "Their models generally assume that all of the upper-plate deformation related to the earthquake cycle is elastic ? recoverable, like an elastic band ? and not permanent. If some of the deformation is permanent, then the models will have to be rethought and more complicated material behaviors used.

The area the researchers studied, the Iquique Gap, "is one of the few places along western South America that has not had a great earthquake in the last 100 years and thus has a high probability of a major earthquake in the next couple of decades," Allmendinger added. "We may get to test out predictions about earthquakes if the next great earthquake there happens in the next couple of decades."

The scientists detailed their findings online April 28 in the journal Nature Geoscience.

Follow OurAmazingPlanet?@OAPlanet, Facebook?and Google+. Original article at LiveScience's OurAmazingPlanet.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/earthquakes-chile-permanently-deformed-earth-170116659.html

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Sunday, April 28, 2013

Some are overlooked in US immigration overhaul

SAN DIEGO (AP) ? Carlos Gonzalez has lived nearly all his 29 years in a country he considers home but now finds himself on the wrong side of the border ? and the wrong side of a proposed overhaul of the U.S. immigration system that would grant legal status to millions of people.

Gonzalez was deported to Tijuana, Mexico, from Santa Barbara in December, one of nearly 2 million removals from the United States since Barack Obama was first elected president.

"I have nobody here," said Gonzalez, who serves breakfasts in a Tijuana migrant shelter while nursing a foot that fractured in 10 places when he jumped the border fence in a failed attempt to rejoin his mother, two brothers and extended family in California. "The United States is all I know."

While a Senate bill introduced earlier this month would bring many of the estimated 11 million people living in the U.S. illegally out of the shadows, not everyone would benefit. They include anyone who arrived after Dec. 31, 2011, those with gay partners legally in the U.S., siblings of U.S. citizens and many deportees such as Gonzalez.

With net immigration from Mexico near zero, the number who came to the U.S. since January 2012 is believed to be relatively small, possibly a few hundred thousand. They include Isaac Jimenez, 45, who paid a smuggler $4,800 to guide him across the California desert in August to reunite with his wife and children in Fresno.

"My children are here, everything is here for me," Jimenez said from Fresno. He lived in the U.S. illegally since 1998 and returned voluntarily to southern Mexico last year to see his mother before she died.

So far, advocates on the left have shown limited appetite to fight for expanded coverage as they brace for a tough battle in Congress. Some take aim at other provisions of the sweeping legislation, like a 13-year track to citizenship they consider too long and $4.5 billion for increased border security.

"It's not going to include everybody," said Laura Lichter, president of the American Immigration Lawyers Association. "It's not perfect. I think you hear a lot of people saying, 'Don't let the perfect be the enemy of the good,' and this is good."

Peter Nunez, who supports restrictive policies as chairman of the Center for Immigration Studies in Washington, rates the bill an 8 or 9 on a scale from 1 to 10, with 10 being the most inclusive. He criticizes a measure that allows deportees without criminal histories to apply for permission to return if they have spouses or children in the U.S. legally, a step that supporters say would reunite families.

"I just don't understand why we are going to basically undo a deportation," said Nunez, a former U.S. attorney in San Diego.

Senate negotiators were more forgiving of criminal records than the Obama administration was when it granted temporary work permits last year to many who came to the U.S. as children. The administration disqualified anyone with a single misdemeanor conviction of driving under the influence, domestic violence, drug dealing or certain other crimes. The Senate bill says only that three misdemeanors or a single felony make someone ineligible.

Deportations topped 400,000 in fiscal 2012, more than double from seven years earlier, sending Mexicans to border cities like Tijuana where they often struggle to find work. The Padre Chava migrant shelter serves breakfast to 1,100 people daily in a bright yellow building that opened three years ago because it outgrew its old quarters. Director Ernesto Hernandez estimates 75 percent are deported.

"Many come wearing sneakers that cost hundreds of dollars and nothing in their pockets," Hernandez said.

About 10 percent of the shelter's deportees speak little or no Spanish, including Salvador Herrera IV, 28, who came to the U.S. when he was 2 in the back seat of a car and grew up skateboarding and playing basketball in Long Beach. With a conviction for grand theft auto putting his legal status out of the question, he is considering paying $8,000 for someone else's identity documents to try to return illegally to Southern California.

"I'm basically American," he said. "I'm a beach boy. I do American stuff."

Many at the shelter have convictions for DUI or domestic violence, said Hernandez, reflecting the Obama administration's priority to target anyone with criminal records for deportation.

Gonzalez was arrested in Santa Barbara on suspicion of disorderly conduct, landing him in Tijuana for New Year's Eve. He said he had several misdemeanor convictions, including a DUI, which he committed shortly after turning 18.

"That's when you party a lot and you think it's not going to matter," he said.

Gonzalez was born in Cuernavaca, south of Mexico City, and came to the U.S. by plane when he was 2 years old, never leaving Santa Barbara. After graduating from Santa Barbara High School in 2002, he took automotive classes at community college, worked about four years at a Jiffy Lube outlet and held jobs as a mechanic, gardener and telemarketer in the picturesque California coastal city of 90,000 people.

Gonzalez doesn't know where he will settle after his foot heals. His family helped with more than $3,000 in medical expenses, including a metal rod that holds a toe together.

He may try to find an aunt in Cuernavaca but doesn't have her phone number or address.

"I never thought I would be in this predicament," he said.

Source: http://news.yahoo.com/overlooked-us-immigration-overhaul-182243975.html

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'Known Lesbian' Reaches Out to Cardinal Without LGBT Friends ...

In mid-April,?Bondings 2.0 reported on a South African cardinal who claimed to know of no LGBT individuals personally, and thus rejected any claims he could be homophobic. Now, a self-ascribed ?known lesbian? has written to Cardinal Wilfrid Fox Napier to challenge his statements, and, in between, presents a novel argument for why Catholic prelates fight so?fiercely?to deny LGBT equality.

Melanie Judge?s piece was published in the?Mail & Guardian, a leading African paper, under the title, ?Hi, Cardinal Napier. I?m lesbian.? She begins by questioning the cardinal?s involvement on issues of sexuality if he knows of no LGBT individuals:

?For someone who doesn?t know any homosexuals, you?ve spent a considerable amount of time concerning yourself with the lives of lesbian and gay people ? specifically our rights to equality and protection under the law.

?If you don?t know us, and then by implication there aren?t any of us in your church, it seems queer that you would assume such an active position in denying us our right to rights.?

Ms. Judge is not content to say that Napier is simply anti-gay. ? Instead, she believes his staunch opposition to South African legislation that would legalize civil unions is merely an attempt to preserve his power, and the power of the Catholic Church, that

??entrenches a version of social relations and human sexuality based on male supremacy, the subordination of women, and the abjection of homosexuality?.Perhaps your investment in the lives of sinful others is driven by an interest in protecting that power and the ideology that props it up. If so, I can understand why you?d rail against gays, lesbians and women who challenge your ideology.?

She continues by shedding light on Napier?s attempt to make LGBT people invisible, which contradicts the Church?s call to acknowledge, welcome, and include LGBT people:

?As you would know, a powerful way to neutralise nonconforming people whose very existence challenges your church?s prescription for human interaction is to make them invisible. To deny the very existence of gay and lesbian people is to render them unknowable and unseeable. Excluding people in this way sends a message to lesbian and gay people in your church (many of whom I know and see, and I?m not even Catholic) that they will be not be acknowledged by your leadership. To deny recognition is to deny human dignity, a strategy at the heart of homophobia.?

Ms. Judge?s comments examine the desperate attempts by Catholic bishops to maintain their privilege in a society structured around heterosexual relationships and male dominance, adding the unique perspective of a South African to her critique of oppression:

?Sexuality and gender were heavily regulated and constrained under apartheid and colonialism. Women and queers ?knew their place? and ?suffered? quietly and invisibly. Now we see a burgeoning of sexual and gender diversity ? it?s exciting stuff, Cardinal. It?s a sign of a plural and democratising society in which ?difference is no longer synonymous with dysfunction.

?Shunning difference and enforcing conformity is how the church has asserted its control over populations for centuries. But this unchecked grip on power has been slipping in the face of democratic pressures. I feel for you, Cardinal; it?s hard to compete with the divine prospect of freedom and equality?

?Queers and women are laying claim to the resources, recognition and representations of citizenship ? both inside and outside the church. It?s the stuff of democracy and of human rights. Still, none so blind as those who will not see.?

Melanie Judge respectfully confronts Cardinal Napier for both the ignorance his statement contains and the the underlying causes driving his anti-LGBT efforts.

?Bob Shine, New Ways Ministry

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Source: http://newwaysministryblog.wordpress.com/2013/04/28/known-lesbian-reaches-out-to-cardinal-without-lgbt-friends/

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Breast-Pump Mom "Humiliated" By Flight Attendant, Barred From In-Flight Pumping

Source: http://www.thehollywoodgossip.com/2013/04/breast-pump-mom-humiliated-by-flight-attendant-barred-from-in-fl/

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Start A Career In Plumbing ? Hot Article Depot

Interested in starting a career as a plumber? Generally poorly stereotyped, a plumbing career can be a great trade skill and provide a great salary. Becoming a plumber is a difficult task with much more training and education than most people realize. You begin your career as an apprentice and, after enough education and hands-on experience you are promoted to journeyman and then, ultimately, awarded master plumber. This process can take anywhere take from ten to fifteen years.

What skills do I need to be a plumber? You might think anyone has the aptitude for plumbing but you would be wrong. Generally a plumber will have skills with math and possess a good deal of manual dexterity and strength. They also have a tolerance for cramped spaces, possess general problem solving skills and have the ability to work well with other people. If you try working with plumbing yourself you will soon realize it can be a complex and difficult task without the proper skills.

The path to master begins with becoming a plumbing apprentice. You can look for a union sponsored program through your state or for a government program intended to create an incentive for learning a trade. These programs combine job training with educational courses. The union sponsored programs often are in high demand and this can often lead to poor acceptance rates and long application times. Do some searching and engage the local union as to what your best opportunities are in the area.

It can be difficult to get accepted into a sponsored program. Thankfully there are alternatives to union-based programs. Look for a trade school or vocational school in your area that offers plumbing certifications. Make sure they are accredited and up-to-date with the state requirements before you enroll. Also try and look for a school with a successful job placement program. This can often take you right into a job someplace as you further your education.

It usually takes about four or five years to complete an apprentice program. Once you?ve completed the trade test you will become a journeyman plumber. In order to become a master plumber, you may have to have from four to five years of experience as a journeyman plumber. In addition, you will have to take a test. This test might cover topics such as federal state and local plumbing codes, plumbing systems, and more. Each state has different requirements and testing, so make sure that you work with your local licensing agency to find out specifically what you will need to do to get your master plumber?s license.

For the best Morristown Plumber at affordable prices, visit the site today!

Source: http://hotarticledepot.com/start-a-career-in-plumbing/

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Boosting the powers of genomic science

Friday, April 26, 2013

As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of.

In a pair of papers published in the April 25, 2013 issue of PLOS Genetics, two diverse teams of scientists, both headed by researchers at the University of California, San Diego School of Medicine, describe novel statistical models that more broadly and deeply identify associations between bits of sequenced DNA called single nucleotide polymorphisms or SNPs and say lead to a more complete and accurate understanding of the genetic underpinnings of many diseases and how best to treat them.

"It's increasingly evident that highly heritable diseases and traits are influenced by a large number of genetic variants in different parts of the genome, each with small effects," said Anders M. Dale, PhD, a professor in the departments of Radiology, Neurosciences and Psychiatry at the UC San Diego School of Medicine. "Unfortunately, it's also increasingly evident that existing statistical methods, like genome-wide association studies (GWAS) that look for associations between SNPs and diseases, are severely underpowered and can't adequately incorporate all of this new, exciting and exceedingly rich data."

Dale cited, for example, a recent study published in Nature Genetics in which researchers used traditional GWAS to raise the number of SNPs associated with primary sclerosing cholangitis from four to 16. The scientists then applied the new statistical methods to identify 33 additional SNPs, more than tripling the number of genome locations associated with the life-threatening liver disease.

Generally speaking, the new methods boost researchers' analytical powers by incorporating a priori or prior knowledge about the function of SNPs with their pleiotrophic relationships to multiple phenotypes. Pleiotrophy occurs when one gene influences multiple sets of observed traits or phenotypes.

Dale and colleagues believe the new methods could lead to a paradigm shift in CWAS analysis, with profound implications across a broad range of complex traits and disorders.

"There is ever-greater emphasis being placed on expensive whole genome sequencing efforts," he said, "but as the science advances, the challenges become larger. The needle in the haystack of traditional GWAS involves searching through about one million SNPs. This will increase 10- to 100-fold, to about 3 billion positions. We think these new methodologies allow us to more completely exploit our resources, to extract the most information possible, which we think has important implications for gene discovery, drug development and more accurately assessing a person's overall genetic risk of developing a certain disease."

"All SNPs are not created equal: Genome-wide association studies reveal a consisten pattern of enrichment among functionally annotated SNPs." Authors include Andrew J. Schork, UCSD Cognitive Sciences Graduate Program, UCSD Center for Human Development and UCSD Multimodal Imaging Laboratory; Wesley K. Thompson and John R. Kelsoe, Department of Psychiatry, UCSD; Phillip Pham, Scripps Health, The Scripps Research Institute (TSRI); Ali Torkamani and Nicholas J. Schork, Scripps Health, TSRI; J. Cooper Roddy, UCSD Multimodal Laboratory; Patrick F. Sullivan, University of North Carolina; Michael C. O'Donovan, Cardiff University, United Kingdom; Helena Furberg, Memorial Sloan Kettering Cancer Center; The Tobacco and Genetics Consortium, The Bipolar Disorder Psychiatric Genomics Consortium, The Schizophrenic Psychiatric Genomics Consortium; and Ole A. Andreassen, UCSD Department of Psychiatry, University of Oslo and Oslo University Hospital.

"Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional False Discovery Rate."

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University of California - San Diego: http://www.ucsd.edu

Thanks to University of California - San Diego for this article.

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Saturday, April 27, 2013

Obama Recess Appointment Case Comes to the Supreme Court (ABC News)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301614359?client_source=feed&format=rss

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Poll: Will you pay $250 for a BlackBerry Q10?

MADRID, April 25 (Reuters) - Playmaker Andres Iniesta has dismissed the idea Barcelona are at the end of an era following their 4-0 Champions League mauling by Bayern Munich. Barca, who lifted the trophy in 2009 and 2011, were the favourites to win the competition ahead of Tuesday's semi-final first leg but they were so outclassed by the Germans that many pundits believe their recent spell of dominance is over. "I think it is unfair to talk of a cyclical change," the Spanish World Cup winner told a news conference on Thursday. ...

Source: http://news.yahoo.com/poll-pay-250-blackberry-q10-173042172.html

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Role of vital proteins in allergic reactions, other conditions

Apr. 25, 2013 ? Itchy eyes, scratchy throat, running nose--it's allergy season! What triggers these allergic reactions, and how do allergy medications work?

The outer surface of many of our cells, including those in the airways, has a protein called the H1 receptor. This protein attaches to histamine, an organic compound involved in immune responses. In some people, the binding triggers allergic reactions, such as hay fever or food and pet allergies. Antihistamine drugs work by preventing histamine from attaching to H1 receptors.

H1 receptors belong to a special family of proteins called G protein-coupled receptors, or GPCRs. Scientists estimate that there are about 800 different types of GPCRs in the membranes of our cells. Some are sensing molecules that let us see, smell and taste; others give us a boost after a few sips of coffee, make us retreat during a conflict or help fight off infection. GPCRs also are associated with diseases ranging from asthma to schizophrenia, and they are the target of more than a third of marketed drugs, including heart medications and antidepressants.

Yet GPCRs' structures--key to understanding how they work and to designing more effective drugs--have remained relatively hidden from view. Researchers funded by the National Institutes of Health have given us a peek at some of them, and the improved methods these scientists have developed could reveal lots more structures in the near future.

Structural Clues

Labs around the world have tried for years to obtain detailed images of human GPCRs because the precise, three-dimensional arrangement of a protein's atoms provides important details about how a protein interacts with its natural partner molecules in the body or with drug molecules. But the structures of membrane proteins, including GPCRs, are as difficult to determine as they are valuable to understand.

One challenge is that GPCRs are exceedingly flimsy and fragile when not anchored within their native cell membranes. This makes it very hard to coax them to form crystals so that their structures can be determined through X-ray crystallography.

Right now, we know the structures of about 1 percent of all human GPCRs, and researchers are using two key approaches to generate and study more. Stanford University's Brian Kobilka, who shared the 2012 Nobel Prize in chemistry for his work on GPCRs, is among the scientists who are focusing on specific GPCRs to better understand how they function and interact with other molecules, including drugs.

Other scientists, such as Raymond Stevens at The Scripps Research Institute, are taking a complementary approach to get structures that represent each of the major branches of the GPCR family tree. Knowing more about one member could enable scientists to computationally model the others.

GPCR

In addition to the H1 histamine receptor, some of the key structures that the Stevens group and its collaborators, including Kobilka and other scientists around the world, have solved using the family tree approach include the:

? ?2 adrenergic receptor, or the molecular "fight or flight" switch.

? A2A adenosine receptor, sometimes called the "caffeine receptor."

? CXCR4 chemokine receptor, which has been linked to more than 20 types of cancer.

?D3 dopamine receptor, which plays a vital role in the central nervous system, affecting our movement, cognition and emotion.

? Kappa opioid receptor, a protein on the surface of brain cells that is centrally involved in pleasure as well as in pain, addiction, depression, psychosis and related conditions.

Technical Breakthroughs

What was the game-changing technical breakthrough that has made determining these structures possible?

"I'm always asked that question," says Stevens, "and the answer is that there wasn't just one breakthrough, there were about 15 separate developments by several different investigators around the world, each breakthrough critically needed in combination with one another, and they came together after a long time."

Some of these breakthroughs have improved researchers' ability to produce and purify GPCRs in quantities sufficient for crystallization. Other breakthroughs have been aimed at stabilizing GPCRs, making them more crystallizable and holding them in a specific structural conformation. Scientists continue to improve other methods, including the ability to model new GPCR structures from known ones.

These developments have had an enormous impact on furthering our understanding of GPCRs, and they should lead to new insights on biological processes and aid progress in drug discovery.

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The above story is reprinted from materials provided by NIH, National Institute of General Medical Sciences (NIGMS), via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/7jU6qt4OqNY/130425103157.htm

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Friday, April 26, 2013

Smartphones out-shipped feature phones for the first time ever worldwide, says IDC

Smartphones outsell feature phones for the first time, says IDC

Q1 2013 marks the first time that smartphones made up the majority of cellphones shipped across the world, according to numbers from industry analyst IDC. 216 million handsets with computer-like functionality left factories compared to 419 million total, making up a solid 51.6 percent of the pie. Another trend spotted by the pollster was the emergence of Chinese phone makers, particularly ZTE and Huawei, who've notably displaced Blackberry and Nokia in the top five for smartphones sold.

Meanwhile, Samsung improved its lead over Apple in smartphone shipments over last quarter, jumping from 29 percent to a 32.7 percent share in Q1, while Apple slid from 21.8 percent to 17.3 percent. Sony dropped out of the top 5 in that category, while LG surged to 3rd place at 10.3 million units shipped, with Huawei and ZTE rounding out the top 5. Meanwhile, Samsung and Nokia continued to dominate overall cellphone shipments with a 27.5 and 14.8 percent share of the overall market, respectively. However, Nokia itself isn't too optimistic about the feature phone portion of those sales continuing, as it mentioned in its last financial statement. And the fact that people are happy to surf the web on their phones? As we've seen, that doesn't bode too well for the computer industry.

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Source: http://www.engadget.com/2013/04/26/smartphones-out-shipped-feature-phones-IDC/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Thursday, April 25, 2013

Museum find proves exotic ?big cat? prowled British countryside a century ago

Apr. 25, 2013 ? The rediscovery of a mystery animal in a museum's underground storeroom proves that a non-native 'big cat' prowled the British countryside at the turn of the last century.

The animal's skeleton and mounted skin was analysed by a multi-disciplinary team of Durham University scientists and fellow researchers at Bristol, Southampton and Aberystwyth universities and found to be a Canadian lynx -- a carnivorous predator more than twice the size of a domestic cat.

The research, published today in the academic journal Historical Biology, establishes the animal as the earliest example of an "alien big cat" at large in the British countryside.

The research team say this provides further evidence for debunking a popular hypothesis that wild cats entered the British countryside following the introduction of the 1976 Wild Animals Act. The Act was introduced to deal with an increasing fashion for exotic -- and potentially dangerous -- pets.

The academics believe such feral "British big cats" as they are known, may have lived in the wild much earlier, through escapes and even deliberate release. There is no evidence that such animals have been able to breed in the wild.

The study of the Canadian lynx, rediscovered by research team member Max Blake among hundreds of thousands of specimens at Bristol Museum and Art Gallery, details records unearthed at the museum which showed the animal had originally been mislabelled by Edwardian curators in 1903 as a Eurasian lynx -- a close relative of the Canadian lynx.

The records also showed that the lynx was shot by a landowner in the Devon countryside in the early 1900s, after it killed two dogs.

"This Edwardian feral lynx provides concrete evidence that although rare, exotic felids have occasionally been part of British fauna for more than a century," said lead researcher, Dr Ross Barnett of Durham University's Department of Archaeology.

"The animal remains are significant in representing the first historic big cat from Britain."

Co-author Dr Darren Naish, from the University of Southampton, added: "There have been enough sightings of exotic big cats which substantially pre-date 1976 to cast doubt on the idea that one piece of legislation made in 1976 explains all releases of these animals in the UK.

"It seems more likely that escapes and releases have occurred throughout history, and that this continual presence of aliens explains the 'British big cat' phenomenon."

The researchers point out in their paper that Eurasian lynxes existed in the wild in Britain many hundreds of years ago, but had almost certainly become extinct by the 7th century. Laboratory analysis of the Bristol specimen's bones and teeth established it had been kept in captivity long enough to develop severe tooth loss and plaque before it either escaped or was deliberately released into the wild. Ancient DNA analysis of hair from the lynx proved inconclusive, possibly due to chemicals applied to the pelt during taxidermy.

Julie Finch, head of Bristol's Museums, Galleries & Archives, said: "Bristol Museum, Galleries and Archives were pleased to be a part of this ground-breaking research, which not only highlights the importance of our science collections, it establishes the pedigree of our 100-year old Lynx and adds to our knowledge and understanding of 'big cats' in the UK.

"Our museum collections are extensive and caring for them requires the considerable skills of our collections officers. We have an amazing collection of taxidermy animals on display and we welcome museum visitors to come along, to take a closer look and discover more about the natural world."

Dr Greger Larson, a member of the research team from Durham University and an expert in the migration of animals, said: "Every few years there is another claim that big cats are living wild in Britain, but none of these claims have been substantiated. It seems that big cats are to England what the Loch Ness Monster is to Scotland.

"By applying a robust scientific methodology, this study conclusively demonstrates that at least one big cat did roam Britain as early as the Edwardian era, and suggests that additional claims need to be subjected to this level of scrutiny."

The lynx is now on public display at Bristol museum.

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The above story is reprinted from materials provided by University of Southampton, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Max Blake, Darren Naish, Greger Larson, Charlotte L. King, Geoff Nowell, Manabu Sakamoto, Ross Barnett. Multidisciplinary investigation of a ?British big cat?: a lynx killed in southern England c. 1903. Historical Biology, 2013; : 1 DOI: 10.1080/08912963.2013.785541

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/CDGCWic5qdo/130424222428.htm

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Lego Mindstorms EV3 kit gets an education, school-friendly platform to ship August 2013

Lego Mindstorms EV3 kit gets an education, schoolfriendly platform to ship August 2013

Lego's new Mindstorms EV3 kit isn't all just gun-firing robots and killer scorpions. Unfortunately, there's also some learning to be done, with the new Mindstorm EV3 kit ready to land in schools this August. Lego reckons the kit touches on several curriculum areas like computer science, math, engineering mixed with (we hope) a little fun -- c'mon, it's class-time Lego!

We got to have a brief play with it back at CES, and as far as Lego goes, it appears to have more than enough additions to keep young minds ticking over, including Linux firmware that connects to Android and iOS apps, infrared and its very own 3D construction guide from Autodesk. The core kit includes the EV3 brick nerve center, a rechargeable battery, sensors, motors, a pile of bricks, a new ball wheel and (thankfully) instructions. Added to that, the teaching set includes a "customizable curriculum", digital workbook and 48 step-by-step tutorials to get the lil' tykes started.

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Source: http://www.engadget.com/2013/04/24/lego-mindstorms-ev3-kit-gets-an-education-school-friendly-platf/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Health insurer WellPoint's 1Q profit rises 3 pct

INDIANAPOLIS (AP) ? WellPoint Inc.'s first-quarter earnings rose about 3 percent to trump analysts' expectations, as the nation's second largest health insurer saw a revenue gain from an acquisition. It also raised its 2013 net income forecast.

Shares of the Indianapolis company rose more than 2 percent Wednesday before markets opened.

The Blue Cross Blue Shield insurer closed its $4.46 billion acquisition of Medicaid coverage provider Amerigroup Corp. late last year, and the acquisition added more than 2 million members to its enrollment in the first quarter. That helped boost the insurer's total membership more than 6 percent in the first quarter to 35.8 million people, a total that trails only UnitedHealth Group Inc.

Medicaid is the state-federal program that provides health coverage for the needy and disabled people, and it represents a growth opportunity for health insurers. States are starting to move residents who qualify for both Medicaid and Medicare, which is a federally-funded program for people over age 65 and the disabled, into managed care programs that improve their care and cut wasteful spending.

WellPoint officials have said the opportunity these "dual eligible" patients offer was a driving force behind the deal.

Many of these patients have chronic or expensive medical conditions, so the additional membership comes with high costs that can balance the extra revenue. WellPoint's benefit expense, or the total it paid in claims, climbed nearly 17 percent to $13.75 billion in the quarter.

Overall, the insurer said Wednesday it earned $885.2 million, or $2.89 per share, in the three months that ended March 31. That's up from $856.5 million, or $2.53 per share, a year ago, when the company had more shares outstanding.

Adjusted earnings totaled $2.94 per share. Analysts forecast earnings of $2.38 per share, according to FactSet.

Operating revenue jumped nearly 16 percent to $17.55 billion. Analysts expected higher revenue of $17.86 billion.

WellPoint now expects 2013 earnings of at least $7.80 per share, up from the $7.60 per share it forecast in January.

Analysts expect, on average, earnings of $7.82 per share.

WellPoint runs Blue Cross Blue Shield plans in 14 states, including California, New York and Ohio. Its stock fell 8 percent last year, as earnings slipped and costs climbed. Former CEO Angela Braly resigned last August after the insurer cut its 2012 forecast and as investor frustration started to surface over the company's performance.

The company then beat analyst expectations in the year's last two quarters, as earnings rose.

BMO Capital Markets analyst Jennifer Lynch said in research note she thinks the company is making progress with its turnaround, given that it beat expectations in the first quarter and raised its annual forecast.

WellPoint named veteran hospital executive Joseph Swedish as its next CEO in February, and he started with the insurer last month. The company's share price has climbed nearly 14 percent so far this year as of Tuesday's close.

The shares gained an additional $1.67, or 2.4 percent, to $71 about 30 minutes before the market opening.

Source: http://news.yahoo.com/health-insurer-wellpoints-1q-profit-rises-3-pct-103538832--finance.html

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How To Make Sure Your Loan is The Right One For You ... - Finance

Clydesdale Bank

A Clydesdale Bank personal loan is intended to help you attain your financial objectives, whatever ideas you may have. A personal loan can really be used for anything and people use them for different reasons; from making their dreams a reality to celebrating a special occasion. ?The most important when deciding on a personal loan is to choose a loan that is right for you and what you?re looking for.

There are 2 different ways to borrow money, secured or unsecured. Secured meaning you have to put up collateral such as equity in your home to secure the loan. Unsecured means you sign your name on the dotted line, the money is yours to do with what you please.? Also when looking for a loan you want to get a fixed rate loan, fixed rate means that you won?t pay any extra interest. The payments will not increase; they will stay the same that way you can plan exactly what your payment will be each month.

The monthly payment arrangement to payback your loan may differ depending on what type of interest rate you get with your loan, or how much you borrow in general.? Depending on what you?re needing the money for of course determines the amount. You also want to make sure that no matter what; you borrow an amount you are certain you can afford, even if your credit allows you to borrow you always want to make sure the payment won?t restrict you monthly.

Now the most fun part of borrowing is what you get to do with your money, there are a myriad of different things to spend your money on.. Make the right decisions and use the right lender and your borrowing with be a great experience!

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Tags: clydesdale bank, loan

Category: Loans

Source: http://www.financecategory.com/how-to-make-sure-your-loan-is-the-right-one-for-you.html

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CA-NEWS Summary

Train plot suspect rejects Canadian law, cites "holy book"

TORONTO (Reuters) - One of two men accused in an alleged al Qaeda-backed plan to derail a passenger train in Canada appeared in court on Wednesday and disputed the authority of Canadian law to judge him, saying the criminal code was not a holy book. Chiheb Esseghaier, a Tunisian-born doctoral student, faces charges that include conspiracy to murder and working with a terrorist group.

U.S. had more tips on Boston suspect; Congress asks questions

WASHINGTON/CAMBRIDGE, Massachusetts (Reuters) - U.S. intelligence knew more about the movements of one of the Boston Marathon bombing suspects than previously reported, U.S. officials said on Wednesday, raising more questions about the government's handling of the case and the sharing of information among agencies. U.S. officials, speaking on the condition of anonymity, said the FBI was alerted when Tamerlan Tsarnaev traveled to Russia last year. They also said Russia, which had tipped off the FBI about its concerns over Tsarnaev in early 2011, made a second, identical request to the CIA in late September 2011.

Iraq on edge after raid fuels deadly Sunni unrest

BAGHDAD, Iraq (Reuters) - More than 30 people were killed in gun battles between Iraqi forces and militants on Wednesday, a day after a raid on a Sunni Muslim protest ignited the fiercest clashes since American troops left the country. The second day of fighting threatens to deepen sectarian rifts in Iraq where relations between Shi'ite and Sunni Muslims are still very tense just a few years after inter-communal slaughter pushed the country close to civil war.

In Myanmar, cheap SIM card draw may herald telecoms revolution

YANGON (Reuters) - Introduced a decade and a half ago under Myanmar's former military rulers, SIM cards sold for as much as $7,000 apiece. Today, they still cost more than $200. From Thursday, lucky winners of a lottery-style sale may get one for as little as $2. This is telecoms deregulation, Myanmar-style.

Baghdad car bomb kills eight people: police

BAGHDAD (Reuters) - At least eight people were killed and 23 more wounded when a car bomb exploded in eastern Baghdad, police and medical sources said on Wednesday. No one claimed responsibility for the blast, but Iraq's al Qaeda wing and other Sunni Islamist insurgents often hit the capital in their campaign to undermine the country's Shi'ite-led government.

Analysis: Iran's unlikely al Qaeda ties: fluid, murky and deteriorating

LONDON (Reuters) - When al Qaeda leader Ayman al-Zawahiri spoke in an audio message broadcast to supporters earlier this month, he had harsh words for Iran. Its true face, he said, had been unmasked by its support for Syrian President Bashar al-Assad against fighters loyal to al Qaeda. Yet it is symptomatic of the peculiar relationship between Tehran and al Qaeda that in the same month Canadian police would accuse "al Qaeda elements in Iran" of backing a plot to derail a passenger train.

Egyptian judges accuse Mursi backers of attacking their independence

CAIRO (Reuters) - Egyptian judges accused President Mohamed Mursi's Muslim Brotherhood on Wednesday of trying to clamp down on judicial independence by conducting a campaign ostensibly aimed at rooting out corruption. A rift between Egypt's Islamist rulers and the judiciary is steadily widening amid a broader struggle over the future character of the country following the 2011 uprising that overthrew autocratic President Hosni Mubarak.

Syrian army seizes strategic town near capital

BEIRUT (Reuters) - Syrian forces loyal to President Bashar al-Assad seized a strategic town east of Damascus on Wednesday, breaking a critical weapons supply route for the rebels, activists and fighters said. Rebels have held several suburbs ringing the southern and eastern parts Damascus for months, but they have been struggling to maintain their positions against a ground offensive backed by fierce army shelling and air strikes in recent weeks.

China's Xinjiang says "terrorist" ax, knife and arson attack kills 21

BEIJING (Reuters) - A confrontation involving axes, knives, at least one gun and ending with the burning down of a house left 21 people dead in China's troubled far-west region of Xinjiang, a government spokeswoman said on Wednesday, calling it a "terrorist attack". It was the deadliest violence in the region since July 2009, when Xinjiang's capital, Urumqi, was rocked by clashes between majority Han Chinese and minority Uighurs that killed nearly 200 people.

Italy president names center-left's Letta as new premier

ROME (Reuters) - Italian President Giorgio Napolitano on Wednesday asked center-left politician Enrico Letta to form a new government, signaling the end of a damaging two-month stalemate since elections in the euro zone's third largest economy in February. Letta, from the Democratic Party (PD), said he would start talks to form a broad-based coalition on Thursday. It is likely to go to parliament for a vote of confidence by early next week.

Source: http://news.yahoo.com/ca-news-summary-000009861.html

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Wednesday, April 24, 2013

What M&M, A&W, and Dozens of Other Acronyms and Initialisms Really Mean

As small businesses grow into large corporations that have to deal with mergers and hostile takeovers, their identities and branding similarly grow, evolve, and often end up being a mish-mash of various names which are then shrunk into acronyms and initialisms to make them easier to remember. A similar thing is done for companies named after their founders, so the folks at Mental Floss did their homework and discovered what several popular acronyms actually stand for. Would Allen & Wright root beer really taste the same? [YouTube via Tastefully Offensive] More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/WbuvKKdz44I/what-mm-aw-and-dozens-of-other-acronyms-and-initialisms-really-mean

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S.Africa's central bank sentiment indicator rises in February

JOHANNESBURG (Reuters) - The South African Reserve Bank's monthly leading business cycle indicator increased 0.1 percent in February from January, as the number of residential building plans approved went up, the bank said on Tuesday.

The indicator collates data such as vehicle sales, job advertisements, business confidence and money supply to gauge the economic outlook.

Indices: 2000 = 100 Feb Jan Dec

Leading Indicator 133.3 132.2 131.8

12-mth percentage change 1.0 1.9 1.2

Coincident Indicator 166.0 166.1

12-mth percentage change 6.7 7.0

Lagging Indicator 106.7 105.9

12-mth percentage change 0.2 0.6

Source: http://news.yahoo.com/africas-central-bank-sentiment-indicator-rises-february-072012609--business.html

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